Are skin rashes typical of follicular lymphoma

Post by Richard
Hi,
I am male 55. I should be getting the consolidated results from pathology
this week or next week. The preliminary diagnostic was "Follicular lymphoma,
large cell, grade 2 of 3". I am most likely stage 3a, 4a.
I have been experiencing skin rashes. a bit since a year or 2. A lot more
since the spring of 2007 (papular eczema like, disappears after days and
weeks of cortico steroid ointment applications). My latest rash is one of
the discoid type (coin like) on the back of the ties and buttock, a little
bit scary. In the last week may be 3 times after breakfast (worst case
around 30 coins), and most of the time takes half a day to diseappear.
I glanced at a picture of someone who had cutaneous t-cell lymphoma and the
rash looked pretty much like mine.
Are these rashes typical of follicular lymphoma?
If yes, what are the regular courses of action.
Could the low-grade follicular be transforming itself into a cutaneous
t-cell lymphoma or any other lymphomas capable of skin involvement.
Could I have several lymphomas at the same time.
Any comments would be appreciated.
Obi-Wan

Skin involvement is not common with follicular lymphoma.
However, non-Hodgkins lymphomas are a very complex group of diseases, and
you'd be much better off asking your oncologist rather than casting around
on a NG

Richard

2007-11-06 00:21:36 UTC

Hi,

Post by Steph
Skin involvement is not common with follicular lymphoma.

However, non-Hodgkins lymphomas are a very complex group of diseases, and
you'd be much better off asking your oncologist rather than casting around
on a NG"

I found this Paragraph at "Wrong Diagnostics"? WD
at the following address

http://www.wrongdiagnosis.com/i/ichthyosis/causes.htm

Under causes of Ichthyosis

"...
Lymphoma

Hodgkin's disease and non-Hodgkin's lymphoma commonly cause scaly rashes.
Hodgkin's disease may cause pruritic scaling dermatitis that begins in the
legs and spreads to the entire body. Remissions and recurrences are common.
Small nodules and diffuse pigmentation are related signs. This disease
typically produces painless enlargement of the peripheral lymph nodes. Other
signs and symptoms include a fever, fatigue, weight loss, malaise, and
hepatosplenomegaly.

Non-Hodgkin's lymphoma initially produces erythematous patches with some
scaling that later become interspersed with nodules. Pruritus and discomfort
are common; later, tumors and ulcers form. Progression produces nontender
lymphadenopathy.
..."

Post by Steph
Skin involvement is not common with follicular lymphoma

I am assuming you could be right, and I am seriously looking at other
potential causes (especially some omega-3 that I am trying to take since the
spring).

Post by Steph
... However, non-Hodgkins lymphomas are a very complex group of diseases,

and you'd be much better off asking your oncologist rather than casting
around
on a NG"

I have received the second opinion from the other institution, it is a
confirmation of the initial diagnostic. I have learned today that my case
will be studied tomorrow by the oncologist group and I might be given
treatment alternatives by the end of the week. I thought it would have taken
weeks or months to get there!. I will try to discuss my skin condition with
the oncologist. Considering the amount and speed of istamine buildup to form
30 coins in less than an hour, I just wonder what would happen if the
reaction would shift to my troat?

I am also Canadian (PQ). The system is free, but apparently overloaded. I am
so far highly frustrated of my experiences since the spring. In our days,
planning anything is difficult, with the healt care system forget about it.

I am surprised to find so few news groups related to the cancer industry
(probably one of the biggest industry on planet earth).

Thanks

Obi-Wan

Steph

2007-11-06 01:58:06 UTC

Post by Steph
Hi,

Post by Steph
Skin involvement is not common with follicular lymphoma.

That is just plain wrong.
You are getting info from some funny places

2007-11-06 12:32:32 UTC

Post by Steph
Hi,

Post by Steph
Skin involvement is not common with follicular lymphoma.

That is just plain wrong.
You are getting info from some funny places

http://www.nature.com/modpathol/journal/v14/n9/abs/3880411a.html
Cutaneous Presentation of Follicular Lymphomas

Renato Franco M.D.1, Amalia Fernández-Vázquez M.D.2, Manuela Mollejo M.D.3,
Miguel A. Cruz M.D.4, Francisca I. Camacho M.D.2, Juan F. García M.D.2, Mercedes
Navarrete B.Sc.2 and Miguel A. Piris M.D.2

1. 1Department of Biomorphological and Functional Science, Federico II
University of Napoli, Italy
2. 2Department of Molecular Pathology, Centro Nacional de Investigaciones
Oncologicas Carlos III, Majadahonda-Madrid, Madrid, Spain
3. 3Department of Pathology, Virgen de la Salud Hospital, Toledo, Spain
4. 4Department of Oncology, Virgen de la Salud Hospital, Toledo, Spain

Correspondence: Miguel A. Piris, Centro Nacional de Investigaciones Oncologicas
Carlos III, Carretera Majadahonda-Pozuelo, km. 2, 28220 Majadahonda, Madrid,
Spain. e-mail: [munged]; fax:[munged]

Accepted 30 March 2001.
The description of primary cutaneous follicular lymphoma has raised interest in
the differential diagnosis of this versus disseminated follicular lymphoma
involving the skin. We report here on four cases of Stage IV follicular
lymphoma, diagnosed in skin biopsy, in which cutaneous lesion was the most
noticeable feature of clinical presentation. In all cases, the morphological
features were superimposed over typical nodal follicular lymphoma. Apart from
classic B-cell markers, they were characterized by CD10 and bcl6 positivity,
markers of follicle germinal center cells; and bcl2 expression, with a
corresponding t(14;18) translocation in three of three cases examined. In all
four cases, bone marrow study and clinical staging revealed disease that had
disseminated since diagnosis. Follow-up showed relapsing cutaneous and nodal
disease in two cases. The only difference observed with a control group of 10
cases of primary cutaneous follicular lymphoma was the absence in this group of
t(14; 18). Disseminated classical follicular lymphoma has to be considered in
the differential diagnosis of follicular lymphoma presenting in the skin. This
series of cases suggests that the presence of t(14;18) could imply the existence
of disease that has disseminated beyond the skin and that cases harboring this
translocation could be candidates for systemic polychemotherapy.

Steph

2007-11-06 15:54:45 UTC

Post by Steph
Hi,

Post by Steph
Skin involvement is not common with follicular lymphoma.

That is just plain wrong.
You are getting info from some funny places

http://www.nature.com/modpathol/journal/v14/n9/abs/3880411a.html
Cutaneous Presentation of Follicular Lymphomas
Renato Franco M.D.1, Amalia Fernández-Vázquez M.D.2, Manuela Mollejo M.D.3,
Miguel A. Cruz M.D.4, Francisca I. Camacho M.D.2, Juan F. García M.D.2, Mercedes
Navarrete B.Sc.2 and Miguel A. Piris M.D.2
1. 1Department of Biomorphological and Functional Science, Federico II
University of Napoli, Italy
2. 2Department of Molecular Pathology, Centro Nacional de
Investigaciones
Oncologicas Carlos III, Majadahonda-Madrid, Madrid, Spain
3. 3Department of Pathology, Virgen de la Salud Hospital, Toledo, Spain
4. 4Department of Oncology, Virgen de la Salud Hospital, Toledo, Spain
Correspondence: Miguel A. Piris, Centro Nacional de Investigaciones Oncologicas
Carlos III, Carretera Majadahonda-Pozuelo, km. 2, 28220 Majadahonda, Madrid,
Spain. e-mail: [munged]; fax:[munged]
Accepted 30 March 2001.
The description of primary cutaneous follicular lymphoma has raised interest in
the differential diagnosis of this versus disseminated follicular lymphoma
involving the skin. We report here on four cases of Stage IV follicular
lymphoma, diagnosed in skin biopsy, in which cutaneous lesion was the most
noticeable feature of clinical presentation. In all cases, the
morphological
features were superimposed over typical nodal follicular lymphoma. Apart from
classic B-cell markers, they were characterized by CD10 and bcl6 positivity,
markers of follicle germinal center cells; and bcl2 expression, with a
corresponding t(14;18) translocation in three of three cases examined. In all
four cases, bone marrow study and clinical staging revealed disease that had
disseminated since diagnosis. Follow-up showed relapsing cutaneous and nodal
disease in two cases. The only difference observed with a control group of 10
cases of primary cutaneous follicular lymphoma was the absence in this group of
t(14; 18). Disseminated classical follicular lymphoma has to be considered in
the differential diagnosis of follicular lymphoma presenting in the skin. This
series of cases suggests that the presence of t(14;18) could imply the existence
of disease that has disseminated beyond the skin and that cases harboring this
translocation could be candidates for systemic polychemotherapy.

And where does it say "Hodgkin's disease and non-Hodgkin's lymphoma commonly
cause scaly rashes"?

2007-11-06 20:21:18 UTC

Post by Steph
Skin involvement is not common with follicular lymphoma.

That is just plain wrong.
You are getting info from some funny places

http://www.nature.com/modpathol/journal/v14/n9/abs/3880411a.html
Cutaneous Presentation of Follicular Lymphomas

And where does it say "Hodgkin's disease and non-Hodgkin's lymphoma commonly
cause scaly rashes"?

It does not. My apology.
J

Richard

2007-11-07 14:33:11 UTC

Hi,

(I wrote)
Lymphoma
Hodgkin's disease and non-Hodgkin's lymphoma commonly cause scaly rashes.

That is just plain wrong.
You are getting info from some funny places
http://www.nature.com/modpathol/journal/v14/n9/abs/3880411a.html
Cutaneous Presentation of Follicular Lymphomas
Renato Franko .... (0ne full page of the above article, see above web

address)

I am writing:

Well, I would tend to agree that your source is somehow a bit more
professional (can't really tell at this point in time).
But thanks to introducing this hard to read article, which I added to my
medical dossier with a note that I strongly feel that my skin involvement
have not been emphasized anough.

Please feel free to tell me if I am wrong about the interpretation of this
article:

- It is a translation and the use of "this" is not anough deterministic
requiring scrutiny and even rendering it intelligible.

Cutaneous presentation of follicular lymphoma
Differential diagnosis

There are:
- primary cutaneous follicular lymphoma (first site of follicular
lymphoma is the skin) no t(14, 18) translocation in skin biopsy
- disseminated follicular lymphoma involving the skin (follicular
lymphoma has spread to the skin) mostly? t(14, 18) in skin biopsy
- skin involvement secondary to follicular lymphoma (ex: mutated cell
necrosis, releasing debris causing skin rashes, ex: week immune system
allowing staf or trep) no lymphoma markers in the skin biopsy
- skin involvement? not related to disease (ex: taking of supplements
causing skin rashes) biopsy not showing follicular markers

From study:

If t(14, 18) in skin biopsy, you have a follicular lymphoma that has spread
to the skin and beyound, and makes it candidate to systemic
polychemotherapy.

My personal comments:
- CT scans and others could indicate spread and involvement of the disease
in the lymph system and outside of the lymph system (of course, skin
involvement requiring a biopsy).

Thanks a lot

Obi-Wan

2007-11-07 08:32:21 UTC

Post by Steph
Skin involvement is not common with follicular lymphoma.

However, non-Hodgkins lymphomas are a very complex group of diseases, and
you'd be much better off asking your oncologist rather than casting around
on a NG"
[...]

Post by Steph
Skin involvement is not common with follicular lymphoma

I am assuming you could be right, and I am seriously looking at other
potential causes (especially some omega-3 that I am trying to take since the
spring).

Post by Steph
... However, non-Hodgkins lymphomas are a very complex group of diseases,

and you'd be much better off asking your oncologist rather than casting
around on a NG"
I have received the second opinion from the other institution, it is a
confirmation of the initial diagnostic. I have learned today that my case
will be studied tomorrow by the oncologist group and I might be given
treatment alternatives by the end of the week. I thought it would have taken
weeks or months to get there!. I will try to discuss my skin condition with
the oncologist. Considering the amount and speed of istamine buildup to form
30 coins in less than an hour, I just wonder what would happen if the
reaction would shift to my troat?
I am also Canadian (PQ). The system is free, but apparently overloaded. I am
so far highly frustrated of my experiences since the spring. In our days,
planning anything is difficult, with the healt care system forget about it.
I am surprised to find so few news groups related to the cancer industry
(probably one of the biggest industry on planet earth).

Richard,
Thanks for your replies to my other questions.
I don't know where my brain is these days.
If you've been wondering where all the other lymphoma patients are, there's 2
web pages, but I prefer this one, probably because a Canadian pointed it out to
us. There's over 1,000 other people with lymphoma here
http://www.nhlcyberfamily.org/

I saw your post on the allergy newsgroup in August and then lost sight of you.
Since you had palpable and generalized lymphadenopathy and will be facing
treatment decisions soon, it's probably the best place for you to discuss these
things with the others there. As Steph mentioned, the lymphomas can be complex,
so I want you with others who can relate to what you're going through.

Some prefer http://www.leukemia-lymphoma.org/hm_lls Discussion Board (on the
left).
They also have peer-to-peer telephone support with a trained volunteer (under
Support), but I don't know if that's only for the Americans..

Come back, from time to time, to let us know how you're doing, ok?
(alt.support.cancer or sci.med.diseases.cancer)
Best wishes,
J

2007-11-06 12:29:24 UTC

It's strange to me that it disappears within half a day.
Do you shower and dress before or after breakfast?
What are you doing to your buttocks and thighs? Sun tanning?
Sitting on something where a cat has slept?

When's the last time the toilet seat was changed or washed?

What pills or supplements do you take around breakfast time?

Post by Richard
I glanced at a picture of someone who had cutaneous t-cell lymphoma and the
rash looked pretty much like mine.

Rashes look all the same to me.
Anything here familiar? http://www.aafp.org/afp/990515ap/2809.html

Post by Richard
Are these rashes typical of follicular lymphoma?
If yes, what are the regular courses of action.
Could the low-grade follicular be transforming itself into a cutaneous
t-cell lymphoma or any other lymphomas capable of skin involvement.
Could I have several lymphomas at the same time.
Any comments would be appreciated.
Obi-Wan

J - trying to rule things out.

Richard

2007-11-07 00:40:37 UTC

Richard wrote: (or I wrote)

It's strange to me that it disappears within half a day.

well half a day + or - some (normal curve)

Post by J
Do you shower and dress before or after breakfast?
What are you doing to your buttocks and thighs? Sun tanning?
Sitting on something where a cat has slept?

I believe that my two main rashes are around points of pressure
- evening in the couch (thighs and buttock)
- daytime on a stool (thighs and lower buttock)
and (foreharms or elbows) on the desk
All papular and discoid now seems to be restrained to these areas. Since
a week in a few times I had a discoid under eczematous? (papular) rash of
the left elbow.

Post by J
When's the last time the toilet seat was changed or washed?

washed last sunday and fairly meticulusly

Post by J
What pills or supplements do you take around breakfast time?

these times, the Budwig stuff (flax seed oil + cottage cheese or yogourt)
inconsistantly accompanying it with (green tea extract, vitamine c,
curcumine)

the rest of the regimen:
no more white or brown sugar
but too much dried fruits (I am cutting on this, not good with flax seed il)
too much fruits (sweet but acidic), will move to more vegetables
omega-3, 2 gels a week
enzymes with serratia peptidase, 2 times a week
i tried to introduce mineral salts but droped it till...

Post by Richard
I glanced at a picture of someone who had cutaneous t-cell lymphoma and the
rash looked pretty much like mine.

Rashes look all the same to me.
Anything here familiar? http://www.aafp.org/afp/990515ap/2809.html

Thats the one. I am glad I wrote "glanced", I made a picture of mine,
and when it recedes it is rather pinkish coins, not brownish nor
continuous areas like picture 5 at the above address.